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Is 223 a suitable replacement for 5.56 defensive loads?

Caveat.....I've read Doc Roberts post on duty 5.56 loads ad naseum and spent way too much time on google....soooo....

5.56 has all but dried up locally.  And what I can find on the web is fairly expensive.

I recently built a 10.5" AR and in the quest for an appropriate defensive load have found that, based on research,  heavier bullets are better and can pull double duty in my SPR.  The issue is all the data I've found/read/watched on youtube utilizes the 5.56 loads.  I can find 75gr PMC OTM rounds locally for fairly cheap (under 20 bucks a box) but they are 223 and not 5.56

Am I just overthinking this whole thing?  Do I loose a ton of effectiveness by using 223 in lieu of 5.56 in typical sub 200 yard ranges?

Thanks in advance.

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