I have a couple of Holosun sights on various AR rigs. I cannot attest to them being duty-worthy, but they appear to be doing quite nicely for me. I have dropped one a couple of times, banged them around more than others would probably would, and have had zero "zero" issues. A short AR platform .22LR with a RDS could be a viable option-------------in very limited cases-------------maybe. A person could rattle off a handful of .22LR rounds right-quick-and-in-a-hurry with minimal noise, recoil, and muzzle rise. Granted, the receiving end would have less than optimum results, but again, a bunch of them would add up to a considerable amount of drama. A very important consideration is one would have to be damn-near at bad-breath-distance in order to get whatever effectiveness there is (relatively speaking.) More than a handful of yards and.....well....things would go from barely good enough to really not good enough.